2024-05-08 17:23 来源：得道网
七鳃鳗圆形的嘴巴周围排列着非常锋利的牙齿，看起来就像你能想象的原始脊椎动物一样。但一项新的研究发现，这种动物与人类有着惊人的相似之处:七鳃鳗拥有负责“战斗或逃跑”反应的神经细胞。这一发现挑战了这部分神经系统在进化史上出现较晚的观点，它使七鳃鳗更接近复杂的脊椎动物——比如人类。
科罗拉多大学博尔德分校的进化生物学家丹尼尔·梅德罗斯(Daniel Meulemans Medeiros)没有参与这项新研究，但之前曾与该研究小组合作过，他说:“这些结论是教科书级别的。”
Sea lampreys (Petromyzon marinus) belong to a group of fish called jawless vertebrates, which scientists thought lacked nervous system characteristics seen in jawed vertebrates, such as the sympathetic nervous system. This system is what’s behind the “fight or flight” response, and it activates the body by releasing hormones to control body temperature and cardiovascular function.
In past work, Caltech neuroscientist Marianne Bronner had examined the lamprey nervous system in detail, specifically the peripheral nervous system, which lies outside of brain and spinal cord, and the neurons in the gut. While studying and developing markers for these neurons, Brittany Edens, a researcher in Bronner’s lab and coauthor of the new study, noticed peripheral neurons outside the lamprey’s intestine. Bronner’s team decided to investigate.
The team used a technique that tags and lights up specific mRNA in individual cells of lamprey embryos. That allowed the researchers to look at three or four genetic factors associated with sympathetic neurons simultaneously. A cluster of cells lining the heart and the trunk of the embryonic lampreys had these genetic factors, indicating that the cells were the sympathetic neurons seen in other vertebrates, the team reports April 17 in Nature.
Next, the team tracked where these cells originated by injecting a dye to label cells of the neural crest, a patch of stem cells that migrate during development and give rise to cells of the peripheral nervous system. The lamprey’s sympathetic neurons lit up with the dye, showing that the cells came from the neural crest, just like they do in more complex vertebrates.
But there were also key differences. Compared with other vertebrates, the lamprey’s sympathetic nervous system formed much later in development and the clusters of cells were smaller. Previous studies may have missed these cells by looking for them at the wrong time during embryo development. So even though the sympathetic system is present, it’s rudimentary nonetheless, Bronner says. “It’s very simplified compared to what it would be in mammals.”
The findings suggest that the sympathetic nervous system was not an innovation of jawed vertebrates, but rather that the blueprint for it has been around since even before lampreys diverged from the main vertebrate line about half a billion years ago, says Shreyas Suryanarayana, a neuroscientist at Duke University who was not involved with the study.
“As you look deeper, it becomes clear that the basic building blocks of these complex systems present in humans are, in fact, very old,” Suryanarayana says. In more complex vertebrates, this system then diversified, expanded and grew larger, he says.
Previous studies had already begun to dismantle the idea of a simple nervous system in lampreys. For example, researchers had found that connections and proteins in specific brain areas of the lamprey resembled those seen in other vertebrates. More recently, scientists found that signaling involved in how the lamprey’s brain organizes itself also applied to all vertebrates.
Medeiros suggests that researchers should now look even further back in evolutionary time at invertebrates to see if they also have sympathetic neurons, which could explain how the vertebrate nervous system evolved.
“That’s really the one of the questions that has fascinated me for years: How did you go from invertebrates to vertebrates?” Bronner says. “I don’t have the answer, but I will keep trying to figure it out.”
